Endocrine Abstracts

We have previously demonstrated that a low dose of hydrocortisone (100 mg) given intravenously suppresses intranuclear NFκB and AP-1 binding and the expression of pro-inflammatory genes like MMPs. We have now investigated the effect of a high dose of hydrocortisone (300 mg=60 mg prednisolone) on NFκB binding and the expression of TLRs, the mediators of TLR signal transduction, MyD88 and TRIF and HMG-B1. Ten normal subjects were injected intravenously with 300 mg of h...